Pdf ebook: Clinical Pharmacology and Therapeutics

Pdf download ebook Clinical Pharmacology and Therapeutics

Summary: A must-have companion for medical students and junior doctors for almost four decades, Lecture Notes: Clinical Pharmacology and Therapeutics provides conci

  • Author :
  • Publisher: John Wiley & Sons
  • ISBN: 1119599962
  • Genre: Medical
  • Number of Pages: 320
  • Language: English
  • Views: 1926
  • Downloads: 1926
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Description: A must-have companion for medical students and junior doctors for almost four decades, Lecture Notes: Clinical Pharmacology and Therapeutics provides concise yet thorough coverage of the principles of clinical pharmacology, the major characteristics of therapeutics, and the practical aspects of prescribing drugs to alleviate symptoms and to treat disease. Whether you are preparing for examinations or prescribing to patients, the tenth edition offers readers current and authoritative insight into the essential practical and clinical knowledge. Logically organised chapters allow for rapid location of key information, while examples of commonly encountered scenarios illustrate how and when to use drugs in clinical situations. Throughout the text, practice questions, prescribing guidelines, and self-assessment tests clarify and reinforce the principles that inform appropriate clinical decision-making. Presents an up-to-date review of drug use across all major clinical disciplines Offers a timely overview of clinical drug trials and development Provides new clinical scenarios to relate chapter content to real-life application Contains colour-coded “Key Points” and “Prescribing Points” to highlight important information Includes chapter introductions and summaries, and numerous figures, tables, and colour illustrations Lecture Notes: Clinical Pharmacology and Therapeutics, Tenth Edition, is an essential resource for medical students, junior doctors, and other prescribers looking for an up-to-date reference on pharmacological principles, prescribing, and therapeutics.


Pdf ebook: Neonatal Clinical Pharmacology and Therapeutics

Pdf download ebook Neonatal Clinical Pharmacology and Therapeutics

Summary: Neonatal Clinical Pharmacology and Therapeutics covers the significant advances in clinical pharmacology and the principles of neonatal therapeutics. This

  • Author : George Rylance,David R. Harvey,Jacob V. Aranda
  • Publisher: Elsevier
  • ISBN: 1483163008
  • Genre: Medical
  • Number of Pages: 302
  • Language: English
  • Views: 1211
  • Downloads: 1211
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Description: Neonatal Clinical Pharmacology and Therapeutics covers the significant advances in clinical pharmacology and the principles of neonatal therapeutics. This book is composed of 20 chapters that tackle various neonatal diseases and their corresponding therapeutic options. The opening chapters review the pharmacological principles and kinetics, placental drug transfer, and drug therapy in pregnancy. The next chapters consider the other aspects of clinical pharmacology, including tocolytics, oxytocin, maternal drug use, neonatal withdrawal, prophylaxis, and the effect of material analgesia and anesthetics on newborn. Considerable chapters are devoted to the treatment options of neonatal diseases, including apnea, pulmonary and systemic disorders, cardiac diseases, jaundice, hypoglycemia, and nutrient deficiencies. The remaining chapters discuss other therapeutic options, such as blood cell component therapy, the use of analgesia and muscle relaxants, and parenteral nutrition. This book is intended primarily for all doctors who care for newborn babies and clinical pharmacologists.


Pdf ebook: Small Animal Clinical Pharmacology and Therapeutics - E-Book

Pdf download ebook Small Animal Clinical Pharmacology and Therapeutics - E-Book

Summary: Confidently utilize the rapidly growing selection of pharmaceuticals used to treat small animals. Small Animal Pharmacology and Therapeutics, 2nd Edition h

  • Author : Dawn Merton Boothe
  • Publisher: Elsevier Health Sciences
  • ISBN: 1437723578
  • Genre: Medical
  • Number of Pages: 1348
  • Language: English
  • Views: 484
  • Downloads: 484
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Description: Confidently utilize the rapidly growing selection of pharmaceuticals used to treat small animals. Small Animal Pharmacology and Therapeutics, 2nd Edition helps you understand both the therapeutic uses of common pharmaceuticals and the pharmacology behind them, giving you all of the information you need to design and modify dosing regimens, identify factors that cause drugs to fail, and anticipate adverse drug reactions. Comprehensive approach emphasizes the use of drugs for prevention as well as treatment. Clear, consistent organization makes it easy to find the information you need when you need it. Dosage tables help you find essential pharmaceutical information at a glance. Pharmacogenetics chapter helps you understand how to use this emerging science to find the right dose for each patient, optimizing efficiency and minimizing toxicity. Routes of administration and sample pharmaceutical calculations provide fast, efficient access to comprehensive drug administration all in one inclusive resource. Multiple chapters on Antimicrobial Drugs and Antimicrobial Therapy highlight the impact of antimicrobial resistance on current practice.


Pdf ebook: Clinical Pharmacology and Therapeutics: Questions for Self Assessment, Third edition

Pdf download ebook Clinical Pharmacology and Therapeutics: Questions for Self Assessment, Third edition

Summary: So you think you've got a handle on therapeutic management? How drugs work and interact with each other, how the body handles them and how drug treatments

  • Author : Timothy G K Mant,Lionel D Lewis,James M Ritter,Albert Ferro
  • Publisher: CRC Press
  • ISBN: 1444113011
  • Genre: Medical
  • Number of Pages: 218
  • Language: English
  • Views: 1189
  • Downloads: 1189
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Description: So you think you've got a handle on therapeutic management? How drugs work and interact with each other, how the body handles them and how drug treatments are assessed? This self-assessment volume allows you to learn, revise and test yourself on all aspects of clinical pharmacology and therapeutics. Four different question types are provided to test your knowledge in this important area - multiple choice questions, extended matching questions, 'best of fives' and problem-solving questions. Detailed explanatory answers ensure this book solves your queries as well as providing essential revision for those all-important exams. Test your knowledge with Clinical Pharmacology and Therapeutics: Questions for Self Assessment and not only develop your exam technique but become a better prescriber.


Pdf ebook: Lecture Notes: Clinical Pharmacology and Therapeutics

Pdf download ebook Lecture Notes: Clinical Pharmacology and Therapeutics

Summary: Lecture Notes: Clinical Pharmacology andTherapeutics provides all the necessary information,within one short volume, to achieve a thorough understandingof

  • Author : Gerard A. McKay,John L. Reid,Matthew R. Walters
  • Publisher: John Wiley & Sons
  • ISBN: 1118297245
  • Genre: Medical
  • Number of Pages: 344
  • Language: English
  • Views: 538
  • Downloads: 538
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Description: Lecture Notes: Clinical Pharmacology andTherapeutics provides all the necessary information,within one short volume, to achieve a thorough understandingof how drugs work, their interaction with the body in health anddisease, and how to use these drugs appropriately in clinicalsituations. Presented in an easy-to-use format, this eighthedition builds on the clinical relevance for which the titlehas become well-known, and features an up-to-date review of druguse across all major clinical disciplines, together with anoverview of contemporary medicines regulation and drugdevelopment. Key features include: A section devoted to the practical aspects ofprescribing Clinical scenarios and accompanying questions to contextualiseinformation End-of-chapter summary boxes Numerous figures and tables which help distil the informationfor revision purposes Whether you need to develop or refresh your knowledge ofpharmacology, Lecture Notes: Clinical Pharmacology andTherpeutics presents 'need to know' information for thoseinvolved in prescribing drugs.


Pdf ebook: A Textbook of Clinical Pharmacology and Therapeutics, 5Ed

Pdf download ebook A Textbook of Clinical Pharmacology and Therapeutics, 5Ed

Summary: If you understand how drugs work (pharmacodynamics), how they are handled by the body (pharmacokinetics), how they interact with each other, and how drug t

  • Author : James Ritter,Lionel Lewis,Timothy Mant,Albert Ferro
  • Publisher: CRC Press
  • ISBN: 1444113003
  • Genre: Medical
  • Number of Pages: 480
  • Language: English
  • Views: 761
  • Downloads: 761
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Description: If you understand how drugs work (pharmacodynamics), how they are handled by the body (pharmacokinetics), how they interact with each other, and how drug treatments are assessed, then you will become a better prescriber. A Textbook of Clinical Pharmacology and Therapeutics gives you that understanding.Fully revised throughout and extensively illust


Pdf ebook: 100 Cases in Clinical Pharmacology, Therapeutics and Prescribing

Pdf download ebook 100 Cases in Clinical Pharmacology, Therapeutics and Prescribing

Summary: 100 Cases in Clinical Pharmacology, Therapeutics and Prescribing explores scenarios commonly seen by medical students and junior doctors in the ward, emerg

  • Author : Kerry Layne,Albert Ferro
  • Publisher: CRC Press
  • ISBN: 0429624530
  • Genre: Medical
  • Number of Pages: 248
  • Language: English
  • Views: 1698
  • Downloads: 1698
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Description: 100 Cases in Clinical Pharmacology, Therapeutics and Prescribing explores scenarios commonly seen by medical students and junior doctors in the ward, emergency department, outpatient clinic or in general practice in which an understanding of pharmacology and sound prescribing practice is central to successful clinical management and safe patient care. A succinct summary of the patient’s history, examination and any initial investigations is followed by questions on the diagnosis and management of the case. The answer includes a detailed discussion on each topic, providing practical advice on how to deal with the challenges that occur when prescribing, including planning, drug calculations, prescription review and adverse drug reactions. The book will be invaluable during clinical placements and is an ideal companion during preparation for the Prescribing Safety Assessment examination. Making speedy and appropriate clinical decisions, and choosing the best course of action to take as a result, is one of the most important and challenging parts of training to become a doctor. These true-to-life cases will teach students and junior doctors to prescribe appropriately, and to hone their diagnostic and management skills.


Pdf ebook: Topics in Clinical Pharmacology and Therapeutics

Pdf download ebook Topics in Clinical Pharmacology and Therapeutics

Summary: Dr. Maronde has performed a major service in bringing together a superb array of scholars and clinicians to discuss not only the basic principles in therap

  • Author : Robert F. Maronde
  • Publisher: Springer Science & Business Media
  • ISBN: 1461248647
  • Genre: Medical
  • Number of Pages: 518
  • Language: English
  • Views: 549
  • Downloads: 549
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Description: Dr. Maronde has performed a major service in bringing together a superb array of scholars and clinicians to discuss not only the basic principles in therapeutics and clinical pharmacology but also the application of those principles to a wide range of clinical problems. Inclusion of chapters on adverse drug reactions, drug overdose, nonmedical prescription drug use, physician prescribing patterns, and the pharmaceutical industry makes this a particularly valuable book for clinicians. It is increasingly important that clinicians be well grounded in the principles of pharmacodynamics and pharmacokinetics because more and more of our patients are aging and cannot be treated as young or middle-aged adults. Elderly patients are liable to either drug overdose or underdose if traditional dosage formulas are followed because of changes in drug metabolism, drug distribution within the body, drug excretion, or changes in receptor site sensitivity. Because the elderly often present with mUltiple chronic diseases and require a variety of medications, they are more prone to medication errors, drug-drug interactions, and adverse drug reactions. The inclusion of three excellent chapters relating to drug-drug interactions, adverse drug reactions, and drug overdose is most welcome and is a valuable addition to this outstanding text on therapeutics and clinical pharmacology. Adverse drug reactions present a potentially serious problem for any patient for whom drugs are prescribed and particularly for those who must take multiple prescriptions.


Pdf ebook: Principles of Clinical Pharmacology

Pdf download ebook Principles of Clinical Pharmacology

Summary: This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focu

  • Author : Arthur J. Atkinson, Jr.,Darrell R. Abernethy,Charles E. Daniels,Robert Dedrick,Sanford P. Markey
  • Publisher: Elsevier
  • ISBN: 9780080466422
  • Genre: Medical
  • Number of Pages: 568
  • Language: English
  • Views: 1907
  • Downloads: 1907
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Description: This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists. Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry Expanded coverage of pharmacogenetics Expanded coverage of drug transporters and their role in interactions Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions A new chapter on drug discovery that focuses on oncologic agents Inclusion of therapeutic antibodies in chapter on biotechnology products


Pdf ebook: Clinical Pharmacology and Therapeutics, An Issue of Veterinary Clinics: Small Animal Practice

Pdf download ebook Clinical Pharmacology and Therapeutics, An Issue of Veterinary Clinics: Small Animal Practice

Summary: A complete update on clinical pharmacology and therapeutics for the small animal practitioner! Topics will include regulatory aspects, pharmacokinetics and

  • Author : Katrina L. Mealey
  • Publisher: Elsevier Health Sciences
  • ISBN: 0323188796
  • Genre: Medical
  • Number of Pages: 204
  • Language: English
  • Views: 1984
  • Downloads: 1984
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Description: A complete update on clinical pharmacology and therapeutics for the small animal practitioner! Topics will include regulatory aspects, pharmacokinetics and clinical practice, idiosyncratic drug toxicity, adverse drug interactions, feline deficiencies, antimicrobials, antibiotic treatment of resistant infections, outpatient analgesics, nutraceuticals, seizure management, immunosuppressive therapy, and much more!


Pdf ebook: Veterinary Pharmacology and Therapeutics

Pdf download ebook Veterinary Pharmacology and Therapeutics

Summary: Veterinary Pharmacology and Therapeutics, Tenth Edition is a fully updated and revised version of the gold-standard reference on the use of drug therapy in

  • Author : Jim E. Riviere,Mark G. Papich
  • Publisher: John Wiley & Sons
  • ISBN: 1118855884
  • Genre: Medical
  • Number of Pages: 1552
  • Language: English
  • Views: 1733
  • Downloads: 1733
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Description: Veterinary Pharmacology and Therapeutics, Tenth Edition is a fully updated and revised version of the gold-standard reference on the use of drug therapy in all major veterinary species. Provides current, detailed information on using drug therapies in all major domestic animal species Organized logically by drug class and treatment indication, with exhaustive information on the rational use of drugs in veterinary medicine Includes extensive tables of pharmacokinetic data, products available, and dosage regimens Adds new chapters on pharmaceutics, ophthalmic pharmacology, food animal pharmacology, and aquatic animal pharmacology Includes access to a companion website with the figures from the book in PowerPoint


Pdf ebook: Medical Pharmacology and Therapeutics E-Book

Pdf download ebook Medical Pharmacology and Therapeutics E-Book

Summary: Medical Pharmacology & Therapeutics, now in its fifth edition, offers medical students all they need to know to become safe and effective prescribers. It f

  • Author : Derek G. Waller,Tony Sampson
  • Publisher: Elsevier Health Sciences
  • ISBN: 0702071900
  • Genre: Medical
  • Number of Pages: 744
  • Language: English
  • Views: 1641
  • Downloads: 1641
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Description: Medical Pharmacology & Therapeutics, now in its fifth edition, offers medical students all they need to know to become safe and effective prescribers. It forms a complete, integrated resource for basic pharmaceutical science, pathophysiology, clinical pharmacology, and therapeutics. The fifth edition has been extensively revised and updated throughout. Key features include: Clear, disease-based approach. Presentation of how drugs are used in clinical practice. Succinct explanations of the major pathogenic mechanisms of each disease and consequent clinical signs and symptoms. Comprehensive reviews of major drug classes relevant to each disease. Structured approach to the principles of disease management – outlining core principles of drug choice and planning a therapeutic regimen for common diseases. Quick-reference drug compendia illustrating key similarities and differences among all BNF-listed drugs in each class. Comes with free e-book on StudentConsult. New sections on key and evolving topics, including prescribing safety and pharmacovigilance. Updated figures to further clarify complex areas. Revised multiple-choice and case-based questions for self-assessment.


Pdf ebook: Clinical Pharmacology: Current Topics and Case Studies

Pdf download ebook Clinical Pharmacology: Current Topics and Case Studies

Summary: Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and a

  • Author : Markus Müller
  • Publisher: Springer Science & Business Media
  • ISBN: 3709101441
  • Genre: Medical
  • Number of Pages: 430
  • Language: English
  • Views: 1827
  • Downloads: 1827
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Description: Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP.


Pdf ebook: Pharmacology and Therapeutics for Dentistry - E-Book

Pdf download ebook Pharmacology and Therapeutics for Dentistry - E-Book

Summary: Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient’s h

  • Author : John A. Yagiela,Frank J. Dowd,Bart Johnson,Angelo Mariotti,Enid A. Neidle
  • Publisher: Elsevier Health Sciences
  • ISBN: 0323078249
  • Genre: Medical
  • Number of Pages: 960
  • Language: English
  • Views: 1196
  • Downloads: 1196
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Description: Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient’s health and optimize dental treatment by factoring in the drugs they take. It explores the basic fundamentals of pharmacology, special topics such as pain control, fear and anxiety, and oral complications of cancer therapy, and most importantly, the actions of specific drug groups on the human body. Whether you’re concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. An emphasis on the dental applications of pharmacology relates drugs to dental considerations in clinical practice. Dental aspects of many drug classes are expanded to include antibiotics, analgesics, and anesthetics. The Alternative Medicine in Dentistry chapter discusses chemicals used as alternative medicines and assesses their potential benefits and risks. The Nonopioid Analgesics chapter groups together non-opioid analgesics, nonsterioidal anti-inflammatory drugs, and antirheumatic and antigout drugs, making these easier to locate and study. Coverage of the endocrine system includes four separate chapters for the most comprehensive coverage. Drug Interactions in Clinical Dentistry appendix lists potential interactions between drugs a patient is taking for nondental conditions and drugs that may be used or prescribed during dental treatment, including effects and recommendations. Glossary of Abbreviations appendix includes the most common abbreviations used for drugs or conditions. New Pharmacogenetics and Pharmacogenomics chapter covers the effects of genetic traits of patients on their responses to drugs. A NEW introductory section offers tips for the study of dental pharmacology and relates pharmacology to dental considerations. An updated discussion of drug-drug interactions covers the harmful effects of mixing medications. Coverage of adverse effects and mechanisms of COX-2 inhibitors, antibiotic prophylaxis, and antiplaque agents explains the dental risks relating to common drug treatments.


Pdf ebook: An Introduction to Mechanisms in Pharmacology and Therapeutics

Pdf download ebook An Introduction to Mechanisms in Pharmacology and Therapeutics

Summary: An Introduction to Mechanisms in Pharmacology and Therapeutics aims to provide some extra information and background reading on modes of action of drugs, b

  • Author : Howard Rogers,Roy G. Spector
  • Publisher: Elsevier
  • ISBN: 1483195511
  • Genre: Medical
  • Number of Pages: 420
  • Language: English
  • Views: 819
  • Downloads: 819
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Description: An Introduction to Mechanisms in Pharmacology and Therapeutics aims to provide some extra information and background reading on modes of action of drugs, but it is not meant to replace existing pharmacology textbooks. It also attempts to show the connection between cell biology and the practice of clinical medicine. This book is organized into 13 chapters that discuss drug-receptor interactions and the influence of drugs on the nervous, respiratory, circulatory, and alimentary systems. They also explain the concepts of pharmacogenetics, intracellular control mechanisms, chemotherapy, and the different types of drugs. This book will be of interest to preclinical and clinical medical students and those preparing for Bachelor of Science degree in Pharmacology and others interested in understanding how drugs work.


Pdf ebook: Clinical Pharmacology During Pregnancy

Pdf download ebook Clinical Pharmacology During Pregnancy

Summary: Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involv

  • Author : Donald Mattison
  • Publisher: Academic Press
  • ISBN: 0123860083
  • Genre: Medical
  • Number of Pages: 488
  • Language: English
  • Views: 763
  • Downloads: 763
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Description: Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are covered, as are research issues, including clinical trial design and ethical considerations. Uses an evidence-based approach for therapeutics during pregnancy Includes a summary of specific medications by indication with up-to-date information on dosing and efficacy in pregnancy for the given indication


Pdf ebook: Clinical Pharmacology and Therapeutics for Veterinary Technicians - E-Book

Pdf download ebook Clinical Pharmacology and Therapeutics for Veterinary Technicians - E-Book

Summary: Grasp complex concepts and develop fundamental knowledge in the rapidly changing field of veterinary pharmacology with Clinical Pharmacology and Therapeuti

  • Author : Robert L. Bill
  • Publisher: Elsevier Health Sciences
  • ISBN: 0323444024
  • Genre: Medical
  • Number of Pages: 480
  • Language: English
  • Views: 760
  • Downloads: 760
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Description: Grasp complex concepts and develop fundamental knowledge in the rapidly changing field of veterinary pharmacology with Clinical Pharmacology and Therapeutics for Veterinary Technicians, 4th Edition. This accessible, comprehensive text explains how drugs work so you can confidently communicate with clients about current drug therapies. Featuring up-to-date drug information and a new full-color design with added illustrations, tables, and boxes, this thorough resource covers drug uses, abuses, calculation errors, and mistakes. Covers complex principles of pharmacology in a manner appropriate for both veterinary technicians and students. Provides strong introductory content on safety, terminology, pharmacy procedures, drug handling (including the latest OSHA requirements), dosage calculations, and pharmacokinetics. Emphasizes the reasons behind drug properties, actions, and effects — not just lists of facts. Valuable clinical applications are interspersed throughout every chapter, and concepts are linked to real-life situations to help reinforce learning. Critical thinking and review questions at the end of every chapter help you test comprehension. UPDATED and NEW! The most up-to-date information on all drug categories and new content on several drugs. NEW! Full-color format with photos and line drawings helps visual learners understand concepts and enhances images’ educational value. NEW! Myths and Misconceptions, Ask Dr. Bill, and You Need to Know boxes break up the narrative and spotlight interesting concepts to make information easier to understand. NEW! Evolve site with instructor resources, including PowerPoint presentations, test bank questions and answers, an image collection, the answer keys to each chapter’s self-assessment questions, and drug calculation practice exercises. NEW! Vet Tech Threads design includes key terms, chapter outlines, and learning objectives, as well as other pedagogical features, to help you grasp key content and navigate through the chapters.


Pdf ebook: Pharmacology and Therapeutics of Cough

Pdf download ebook Pharmacology and Therapeutics of Cough

Summary: The last decade or so has seen remarkable advances in our knowledge of cough. This applies especially to its basic mechanisms: the types of airway sensors,

  • Author : K. Fan Chung,John Widdicombe
  • Publisher: Springer Science & Business Media
  • ISBN: 3540798420
  • Genre: Medical
  • Number of Pages: 376
  • Language: English
  • Views: 376
  • Downloads: 376
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Description: The last decade or so has seen remarkable advances in our knowledge of cough. This applies especially to its basic mechanisms: the types of airway sensors, the phar- cological receptors on their membranes, the brainstem organization of the ‘cough centre’, and the involvement of the cerebral cortex in the sensations and the vol- tary control of cough. With the exception of the last of these, nearly all the studies have been on experimental animals rather than humans, for obvious reasons. One group of experimental studies has particular relevance to human patients, and that is the demonstration of the sensitization of cough pathways both in the periphery and in the brainstem. Similar sensitizations have been shown for patients with chronic cough or who have been exposed to pollutants, and it is reasonable to suppose that this is the basis of their cough and that the underlying mechanisms are generally similar in humans and other species. Important advances are also being made in clinical cough research. For the three main causes of clinical cough, asthma, post-nasal drip syndrome, and gast- oesophageal re?ux disease, we are beginning to understand the pathological processes involved. There remains a diagnostically obdurate group of idiopathic chronic coughers, but even for them approaches are being devised to clarify und- lying mechanisms and to establish diagnoses. Perhaps surprisingly, the ?eld in which there has been the least spectacular - vance is the therapy of cough.


Pdf ebook: Drug-Drug Interactions

Pdf download ebook Drug-Drug Interactions

Summary: Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicol

  • Author : A. David Rodrigues
  • Publisher: CRC Press
  • ISBN: 0849375940
  • Genre: Medical
  • Number of Pages: 768
  • Language: English
  • Views: 672
  • Downloads: 672
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Description: Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes


Pdf ebook: Pharmacology and Pharmacotherapeutics - E-Book

Pdf download ebook Pharmacology and Pharmacotherapeutics - E-Book

Summary: A classic Pharmacology book trusted equally by students and practicing physicians for its up-to-date, accurate and reliable text, which has always placed b

  • Author : RS Satoskar,Nirmala Rege,SD Bhandarkar
  • Publisher: Elsevier Health Sciences
  • ISBN: 8131243710
  • Genre: Medical
  • Number of Pages: 1170
  • Language: English
  • Views: 1060
  • Downloads: 1060
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Description: A classic Pharmacology book trusted equally by students and practicing physicians for its up-to-date, accurate and reliable text, which has always placed before the readers an integrated approach intertwining current knowledge of pathophysiology of the disease, pharmacology of available drugs and strategies for medical management of diseases. • Trusted Pharmacology book with emphasis on pathophysiology, clinical pharmacology and therapeutics, presenting information in integrated manner. • Up-to-date information supplemented with tables and diagrams, having: - therapy of important diseases presented in boxes. - current guidelines to support therapeutic decisions - tips for practising physicians. • Uses integrated approach intertwining current knowledge of pathophysiology of the disease, pharmacology of available drugs and strategies for medical management of diseases. • Balances the complexity and simplicity of scientific content to provide students of medicine and/or pharmacy an insight into rational therapeutics.


Pdf ebook: Introduction to Clinical Pharmacology - E-Book

Pdf download ebook Introduction to Clinical Pharmacology - E-Book

Summary: Emphasizing safe and effective drug administration, Introduction to Clinical Pharmacology, 10th Edition, helps you understand the principles of pharmacolog

  • Author : Constance G Visovsky,Cheryl H Zambroski,Shirley Hosler
  • Publisher: Elsevier Health Sciences
  • ISBN: 0323755364
  • Genre: Medical
  • Number of Pages: 416
  • Language: English
  • Views: 1770
  • Downloads: 1770
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Description: Emphasizing safe and effective drug administration, Introduction to Clinical Pharmacology, 10th Edition, helps you understand the principles of pharmacology and prevent medication errors. It promotes safety by showing how drugs and drug classes work, so you can understand why drugs are given, as well as the adverse effects and drug interactions that may occur. A thorough nursing process section with each drug class outlines the nurse’s role when administering drugs. The updated Get Ready for the Next Generation NCLEX® Examination! feature offers case studies with Next Generation NCLEX-format questions to help you prepare for the new licensure examination. Ideal scope of content and readability for LPN/LVN programs includes basic, need-to-know pharmacology content. Safety Alert boxes highlight important nursing considerations for safe medication administration and monitoring. Lifespan Considerations boxes for children and older adults draw attention to information that would be especially important when giving a specific drug to patients of those age groups. A focus on understanding drug classes helps students understand the actions and uses of drug classes and provides a framework for safe, effective practice as new drugs are introduced to the market. Video clips on medication administration procedures provide students with a visual reference for safe medication administration. Key terms with phonetic pronunciations and text page references help improve students’ terminology and language skills before they enter clinical practice. Essential content is highlighted throughout the text, as in all of Elsevier’s LPN Threads textbooks, with features such as Top Tips for Safety, Memory Joggers, and Lifespan Considerations boxes. NEW! Get Ready for the Next Generation NCLEX® Examination! section includes key points, review questions, and case studies with Next Generation NCLEX-format questions to prepare students for the new licensure examination. NEW! Reorganized chapters break up lengthy content and more logically present pharmacological content by body system or major disorder. UPDATED! Coverage of newly approved and updated pharmaceutical treatments and drugs prepares students for practice.


Pdf ebook: Mechanisms of Drug Action

Pdf download ebook Mechanisms of Drug Action

Summary:

  • Author : G.N. Woodruff
  • Publisher: Springer
  • ISBN: 1349080268
  • Genre: Medical
  • Number of Pages: 258
  • Language: English
  • Views: 1638
  • Downloads: 1638
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Description:


Pdf ebook: Drugs in Psychiatry

Pdf download ebook Drugs in Psychiatry

Summary: Part of the Drugs in series, the updated second edition of this practical pocketbook summarizes essential information on all the major drugs currently used

  • Author : Basant K. Puri
  • Publisher: OUP Oxford
  • ISBN: 0191649279
  • Genre: Medical
  • Number of Pages: 240
  • Language: English
  • Views: 393
  • Downloads: 393
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Description: Part of the Drugs in series, the updated second edition of this practical pocketbook summarizes essential information on all the major drugs currently used in clinical psychiatric practice. Beginning with a brief discussion on drugs in psychiatry, the text moves on to consider the principles of psychopharmacology, which form the foundation of the sound, scientifically based use of drugs in psychiatry. Details are then given, in turn, of the main non-depot antipsychotic drugs, antipsychotic depot injections, antimanic drugs, tricyclic and related antidepressant drugs, monoamine-oxidase inhibitors, selective serotonin re-uptake inhibitors, and other antidepressants. This practical pocketbook is an essential companion for all medical staff involved in psychopharmacology, both for learning and quick reference.


Pdf ebook: Oligonucleotide-Based Drugs and Therapeutics

Pdf download ebook Oligonucleotide-Based Drugs and Therapeutics

Summary: A comprehensive review of contemporary antisense oligonucleotides drugs and therapeutic principles, methods, applications, and research Oligonucleotide-bas

  • Author : Nicolay Ferrari,Rosanne Seguin
  • Publisher: John Wiley & Sons
  • ISBN: 1119070309
  • Genre: Medical
  • Number of Pages: 576
  • Language: English
  • Views: 1481
  • Downloads: 1481
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Description: A comprehensive review of contemporary antisense oligonucleotides drugs and therapeutic principles, methods, applications, and research Oligonucleotide-based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide covering all key aspects of this increasingly popular area of pharmacology and biotech and pharma research, from the basic science behind antisense oligonucleotides chemistry, toxicology, manufacturing, to safety assessments, the design of therapeutic protocols, to clinical experience. Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence. While the idea of antisense oligonucleotides to target single genes dates back to the 1970's, most advances have taken place in recent years. The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in the delivery of oligonucleotides. This valuable book reviews the fundamentals of oligonucleotides, with a focus on antisense oligonucleotide drugs, and reports on the latest research underway worldwide. • Helps readers understand antisense molecules and their targets, biochemistry, and toxicity mechanisms, roles in disease, and applications for safety and therapeutics • Examines the principles, practices, and tools for scientists in both pre-clinical and clinical settings and how to apply them to antisense oligonucleotides • Provides guidelines for scientists in drug design and discovery to help improve efficiency, assessment, and the success of drug candidates • Includes interdisciplinary perspectives, from academia, industry, regulatory and from the fields of pharmacology, toxicology, biology, and medicinal chemistry Oligonucleotide-Based Drugs and Therapeutics belongs on the reference shelves of chemists, pharmaceutical scientists, chemical biologists, toxicologists and other scientists working in the pharmaceutical and biotechnology industries. It will also be a valuable resource for regulatory specialists and safety assessment professionals and an important reference for academic researchers and post-graduates interested in therapeutics, antisense therapy, and oligonucleotides.


Pdf ebook: Atkinson's Principles of Clinical Pharmacology

Pdf download ebook Atkinson's Principles of Clinical Pharmacology

Summary: Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualizatio

  • Author : Shiew-Mei Huang,Juan J.L. Lertora,Paolo Vicini,Arthur J. Atkinson, Jr.
  • Publisher: Academic Press
  • ISBN: 0128198842
  • Genre: Medical
  • Number of Pages: 762
  • Language: English
  • Views: 949
  • Downloads: 949
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Description: Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. Presents the essential knowledge for effective practice of clinical pharmacology Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology Offers an extensive regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK


Pdf ebook: Pharmaceutical Medicine

Pdf download ebook Pharmaceutical Medicine

Summary: The breadth of the pharmaceutical medicine can be daunting, but this book is designed to navigate a path through the speciality. Providing a broad overview

  • Author : Adrian Kilcoyne,Phil Ambery,Daniel O'Connor
  • Publisher: OUP Oxford
  • ISBN: 0191510394
  • Genre: Medical
  • Number of Pages: 480
  • Language: English
  • Views: 412
  • Downloads: 412
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Description: The breadth of the pharmaceutical medicine can be daunting, but this book is designed to navigate a path through the speciality. Providing a broad overview of all topics relevant to the discipline of pharmaceutical medicine, it gives you the facts fast, in a user-friendly format, without having to dive through page upon page of dense text. With 136 chapters spread across 8 sections, the text offers a thorough grounding in issues ranging from medicines regulation to clinical trial design and data management. This makes it a useful revision aid for exams as well as giving you a taster of areas of pharmaceutical medicine adjacent to your current role. For healthcare professionals already working in the field, this book offers a guiding hand in difficult situations as well as supplying rapid access to the latest recommendations and guidelines. Written by authors with experience in the industry and drug regulation, this comprehensive and authoritative guide provides a shoulder to lean on throughout your pharmaceutical career.


Pdf ebook: Pharmacology of Asthma

Pdf download ebook Pharmacology of Asthma

Summary: This volume forms part of a prestigious series and covers the latest advances in our understanding of the pathophysiology and treatment of asthma. Our unde

  • Author : Clive P. Page,Peter J. Barnes
  • Publisher: Springer Science & Business Media
  • ISBN: 364275855X
  • Genre: Medical
  • Number of Pages: 320
  • Language: English
  • Views: 547
  • Downloads: 547
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Description: This volume forms part of a prestigious series and covers the latest advances in our understanding of the pathophysiology and treatment of asthma. Our understanding of asthma has changed dramatically in recent years, and much of this new information is brought together in this volume written by inter nationally recognised authorities. The aim of the book is to review in depth the changing concepts of inflammatory processes in asthma and to discuss the implications for research of this common chronic disease. Many of the advances in and future therapy our understanding of asthma have originated from a pharmacological approach, and this volume highlights the promising new options for pharma cological intervention. It is hoped this book will be invaluable for research scientists and clinic ians involved in asthma research and will be a major reference resource for chest physicians and those involved in the development of novel pharmaceu tical entities. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this growing area. c.P. PAGE P.l. BARNES Contents CHAPTER 1 The Pathology of Asthma: An Overview L.A. LAmNEN and A. LAmNEN. With 10 Figures ...................... 1 A. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 1 . . . . . . . . . . . . . . . B. Methods to Investigate the Pathology of Human Asthma ............ 1 C. Bronchial Epithelium and Inflammatory Cells in Asthmatic Patients Between Attacks ........................... 2 I. Mast Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 4 . . . . . . . . . . . . . . II. Eosinophils ............................................... 7 III. Neutrophils.............................................. 10 D. Bronchial Epithelial Inflammation During an Asthma Attack. . . . . .. . 10 E. Epithelial Regeneration .... . . . . . . . . . . . . . . . . . . . . . . .. . . 12 . . . . . . . . .


Pdf ebook: Basic and Clinical Pharmacology 15e

Pdf download ebook Basic and Clinical Pharmacology 15e

Summary: Master key pharmacological concepts and practices with the most comprehensive, authoritative guide available Presented in full-color and packed with hundre

  • Author : Bertram G. Katzung,Anthony J. Trevor
  • Publisher: McGraw Hill Professional
  • ISBN: 1260452328
  • Genre: Medical
  • Number of Pages: 1328
  • Language: English
  • Views: 445
  • Downloads: 445
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Description: Master key pharmacological concepts and practices with the most comprehensive, authoritative guide available Presented in full-color and packed with hundreds of illustrations, Basic and Clinical Pharmacology is the wide-ranging, engaging guide students have counted on for decades. Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, the guide covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!. Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters New chapter on the increasingly relevant topic of cannabis pharmacology Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019 New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters


Pdf ebook: Workbook and Casebook for Goodman and Gilman’s The Pharmacological Basis of Therapeutics

Pdf download ebook Workbook and Casebook for Goodman and Gilman’s The Pharmacological Basis of Therapeutics

Summary: A new companion study guide to the most respected text in pharmacy education Goodman & Gilman’s Workbook for Pharmacologic Therapeutics delivers concise,

  • Author : Douglas Rollins,Donald Blumenthal
  • Publisher: McGraw Hill Professional
  • ISBN: 0071793372
  • Genre: Medical
  • Number of Pages: 384
  • Language: English
  • Views: 1249
  • Downloads: 1249
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Description: A new companion study guide to the most respected text in pharmacy education Goodman & Gilman’s Workbook for Pharmacologic Therapeutics delivers concise, high-yield summaries of the world-renowned coverage of the actions and uses of therapeutic agents in relation to physiology and pathophysiology found in Goodman & Gilman’s The Pharmacological Basis of Therapeutics. In order to maximize the learning and teaching experience, this unique review is packed with pedagogical aids such as learning objectives, summaries of key points, self-assessment Q&A, case vignettes, and a complete test bank in the final chapter. Perfect as a self-study guide or as a required classroom review, Goodman & Gilman’s Workbook for Pharmacologic Therapeutics contains features and content that will appeal to both students and professors.


Pdf ebook: Applied Clinical Pharmacokinetics 3/E

Pdf download ebook Applied Clinical Pharmacokinetics 3/E

Summary: The most current, hands-on book in the field, Applied Clinical Pharmacokinetics The perfect textbook for pharmacy students learning the clinical applicatio

  • Author : Larry A. Bauer
  • Publisher: McGraw Hill Professional
  • ISBN: 007179459X
  • Genre: Medical
  • Number of Pages: 816
  • Language: English
  • Views: 300
  • Downloads: 300
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Description: The most current, hands-on book in the field, Applied Clinical Pharmacokinetics The perfect textbook for pharmacy students learning the clinical application of pharmacokinetics, which is the mathematical tools for modifying doages. Students like that each chapter includes sample problems throughout the chapter, with a ton of practice problems at the end. Answers for the practice problems are in the back, but not detailed like the sample problems) *Changes in the 3/e includes: *All chapters updated and revised, as needed, including critical new references *Antibiotic individualization and monitoring sections increases use of pharmacodynamic parameters (Cmax/MIC, AUC24/MIC, Time above MIC) in addition to pharmacokinetic parameters to adjust dosages *Anticonvulsants section includes 5 new agents (Fosphenytoin, Lamotrigine, Levetiracetam, Oxcarbazepine, Eslicarbazepine) *Immunosuppressants section includes 1 new agent (Sirolimus), About the Book Text focuses on the latest standardized techniques and approaches to patient-specific dosing and provides up-to-date information on more recently moniotored drugs. Features Clear, useful coverage of drug dosing and drug monitoring Clear and concise summary of pharmacokinetic and pharmacodynamic concepts Practical help with calculations and equations Focus on the latest standardized techniques and approaches to patient-specific dosing Up-to-date information on more recently monitored drugs Essential information on drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure All the information practitioners need on drug categories such as antibiotics, cardiovascular agents, anticonvulsants, and immunosuppressants Full coverage of drugs such as Aminoglycosides, Vancomycin, Digoxin, Phenytoin, Carbamazepine, Theophylline, Cyclosporine, Tacrolimus, and Lithium Student friendly approach to teaching pharmacokinetics--sample problems embedded into the text to allow for students to apply what they are learing. .


Pdf ebook: Final Hurdle, The: Single Best Answers In Clinical Pharmacology And Therapeutics

Pdf download ebook Final Hurdle, The: Single Best Answers In Clinical Pharmacology And Therapeutics

Summary: A comprehensive learning tool to aid preparation for undergraduate pharmacology examinations, this study guide focuses on reinforcing core concepts, improv

  • Author : Dholakia Shamik,John Christopher D,Schachter Michael
  • Publisher: World Scientific Publishing Company
  • ISBN: 1911298631
  • Genre: Medical
  • Number of Pages: 248
  • Language: English
  • Views: 305
  • Downloads: 305
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Description: A comprehensive learning tool to aid preparation for undergraduate pharmacology examinations, this study guide focuses on reinforcing core concepts, improving exam technique and developing confidence in answering the style of questions used in the examinations.Its aim is to provide an aid to learning and self-assessment for undergraduates in medicine and other health professionals. The importance of ensuring patient safety and the quality of patient care is becoming more important nationally and internationally, after a period when it was perhaps somewhat neglected in some academic centres. Though this study guide is not a substitute for a comprehensive text on the subject, it will be a useful aid for revision.There is no current single best answer book available to final year medical students to help them prepare for their final exams. A good and strong understanding of clinical pharmacology and therapeutics is an essential foundation in the development of a medical career, and this book highlights the core concepts through a systematic approach, building confidence in the ability to answer pertinent questions and also reinforcing learning./a


Pdf ebook: Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics

Pdf download ebook Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics

Summary: Handbook of Basic and Clinical Ocular Pharmacology provides a review of the basic anatomy, physiology, biochemistry and pathology of the eye with a focus d

  • Author : Naj Sharif,Sunny Ohia
  • Publisher: Academic Press
  • ISBN: 0128192925
  • Genre: Medical
  • Number of Pages: 420
  • Language: English
  • Views: 941
  • Downloads: 941
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Description: Handbook of Basic and Clinical Ocular Pharmacology provides a review of the basic anatomy, physiology, biochemistry and pathology of the eye with a focus drug therapy, drug delivery and use of therapeutic medical miniature devices. An understanding of the pharmacological actions of drugs acting on the eye requires the student and health care practitioner to learn additional principles in basic and clinical sciences that are unique to this organ. As a sensory organ, the eye is relatively inaccessible to the systemic circulation due to the blood-vitreous, blood-aqueous and blood-retinal barriers. Consequently, the administration of drugs for therapeutic effects in the eye necessitates an understanding of physico-chemical properties of the molecules and pharmacokinetic principles involved in the access to its site of action via topical, intracameral and intravitreal administration. This book includes information on the general principles of pharmacokinetics and pharmacodynamics of drugs as it pertains to the eye and in combating ocular disorders and diseases. Using a disease-themed approach, the book discusses basic and clinical pharmacological principles involved in the therapy of these diseases including the ocular side effect of systemically-administered drugs, drugs used in ophthalmic surgery and miscellaneous agents, the therapeutic utility of biologics, drug conjugates, combination products, gene and cellular therapy are also covered. Handbook of Basic and Clinical Ocular Pharmacology is useful as a primary and secondary source of reference for up-to-date information about the pharmacological mechanisms of action, pharmacokinetics, side effects, drug-drug interactions and therapeutic indications of drugs for pharmacologists, pharmaceutical scientists, students in the health care disciplines (nursing, pharmacy, optometry, medical), and practitioners in optometry and ophthalmology. Explains the mechanisms of action, side-effects and therapeutic uses of drugs, biologics, miniature devices, gene and cellular therapies for the eye Provides a comprehensive review of the anatomy, physiology, biochemistry, pharmacology, microbiology, genetics and pathology of parts of the eye involved in drug therapy to combat eye disorders and diseases Explores the pharmacological and clinical basis of drugs, drug conjugates, combination products used in the treatment of anterior and posterior segment diseases


Pdf ebook: Principles of Clinical Pharmacology

Pdf download ebook Principles of Clinical Pharmacology

Summary: Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and co

  • Author : Arthur J. Atkinson, Jr.,Shiew-Mei Huang,Juan J.L. Lertora,Sanford P. Markey
  • Publisher: Academic Press
  • ISBN: 0123854725
  • Genre: Medical
  • Number of Pages: 652
  • Language: English
  • Views: 1529
  • Downloads: 1529
  • GET BOOK

Description: Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science. The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions Offers an expanded regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III


Pdf ebook: Pharmacology of Ocular Therapeutics

Pdf download ebook Pharmacology of Ocular Therapeutics

Summary: This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, p

  • Author : Thirumurthy Velpandian
  • Publisher: Springer
  • ISBN: 3319254987
  • Genre: Medical
  • Number of Pages: 535
  • Language: English
  • Views: 1667
  • Downloads: 1667
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Description: This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. Applications of extemporaneously prepared formulations are described to inform day-to-day clinical practice. The use of mucoadhesive polymers in tear substitutes, ocular drug delivery systems, stem cell therapy, pharmacogenomics and antiangiogenic ocular chemotherapy are also explored. The book also provides insights from drugs of herbal origin, and a historical perspective on drugs for ocular use. Practicing and resident ophthalmologists, optometrists, pharmacists, nursing professionals, scholars in ocular drug research and students will equally benefit from this comprehensive guide.


Pdf ebook: The Physiological Basis of Veterinary Clinical Pharmacology

Pdf download ebook The Physiological Basis of Veterinary Clinical Pharmacology

Summary: The diversity of species in which drugs are used for clinical purposes and the emphasis on various classes of drugs make veterinary pharmacology a complex

  • Author : J. Desmond Baggot
  • Publisher: John Wiley & Sons
  • ISBN: 0470680296
  • Genre: Medical
  • Number of Pages: 296
  • Language: English
  • Views: 1919
  • Downloads: 1919
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Description: The diversity of species in which drugs are used for clinical purposes and the emphasis on various classes of drugs make veterinary pharmacology a complex subject. Anatomical and physiological features influence the pharmacokinetic behaviour of a drug in a particular animal and the dosage required. This book is concerned with the basis of species differences, the selection of pharmacokinetic parameters and the interpretation of values obtained. There are chapters on bioavailability and its application to veterinary dosage forms, changes in drug disposition and interspecies scaling, clinical selectivity and stereoisomerism, drug permeation, antimicrobial disposition and specifics related to neonatal animals. The author has gathered all this information together in one place so allowing the reader to make better selection of drug preparations for animal dosages to effectively treat animal diseases. The book will prove valuable to clinical researchers in the areas of pharmacology, anaesthesia, microbial infections and, internal medicine as well as postgraduate students of these disciplines. The Author J Desmond Baggot (MVM, PhD, DSc, FRCVS, DipECVPT) is currently Visiting Professor of Veterinary Pharmacology at the School of Veterinary Medicine, St George's University, Grenada, West Indies. He was a contributing author and co-author of Antimicrobial Therapy in Veterinary Medicine, 3rd Edition (2000) and Development and Formulation of Veterinary Dosage Forms, 2nd Edition (1998) and the author of Principles of Drug Disposition in Domestic Animals (1977). Elucidations of the processes that underline species variation in the disposition of drugs and interpretation of the influence of disease states on drug disposition have been the focus of his research endeavours. He was a member of the Editorial Board of the Journal of Veterinary Pharmacology and Therapeutics from 1978 to 1996. He is a former Professor of Clinical Pharmacology at the School of Veterinary Medicine, University of California, Davis and Preclinical Veterinary Studies at the University of Zimbabwe, Harare.


Pdf ebook: Manual for the Planning and Implementation of Therapeutic Studies

Pdf download ebook Manual for the Planning and Implementation of Therapeutic Studies

Summary: The German edition of this manual appeared in 1979. Its main objective then was to extend help to those engaged in multiaentric therapeutic studies, especi

  • Author : S. Biefang,W. Köpcke,M.A. Schreiber
  • Publisher: Springer Science & Business Media
  • ISBN: 3642932371
  • Genre: Medical
  • Number of Pages: 103
  • Language: English
  • Views: 508
  • Downloads: 508
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Description: The German edition of this manual appeared in 1979. Its main objective then was to extend help to those engaged in multiaentric therapeutic studies, especially with respect to the "Federal Government's Program on Promoting Research and Development in the Service of Health". Experience with therapeutic studies in the Federal Republic of Germany showed that considerable problems as to methods and implementation of such studies exist. The manual was an attempt to present current metho dological knowledge and the experience obtained from completed studies in the light of the international literature. No radically new methodo logy was produced; however, the information representing the state-of the art, which is widely scattered up to now, has been compiled. For the American edition of this manual a few changes have been made. These concern especially the literature where references to German un published manuscripts were omitted. The authors wish to thank Dr. Andreas Jaffe for the translation, and Evelyn Birke who typewrited the lecture-notes manuscrip~ • . GUnzburg and Munich Sibylle Biefang November 1981 Wolfgang Kopcke Martin A. Schreiber Contents Page Foreword 1. Methods of Therapeutic Studies 2 1. 1. Terminology 4 1. 2. Experimental Design 11 1. 3. Types of Studies 20 1. 4. Steps in Drug Testing 2. Checklist for the Planning, Implementation and Evaluation 22 of Therapeutic Studies 22 2. 1. Planning of Experiments 29 2. 2. Documentation 36 2. 3. Organization 41 2. 4. Statistical Analysis 44 2. 5.


Pdf ebook: Clinical Pharmacology for the Oral and Maxillofacial Surgeon, An Issue of Oral and Maxillofacial Surgery Clinics of North America, E-Book

Pdf download ebook Clinical Pharmacology for the Oral and Maxillofacial Surgeon, An Issue of Oral and Maxillofacial Surgery Clinics of North America, E-Book

Summary: In this issue of Oral and Maxillofacial Surgery Clinics, guest editor Harry Dym brings his considerable expertise to the topic of Clinical Pharmacology for

  • Author : Harry Dym
  • Publisher: Elsevier Health Sciences
  • ISBN: 0323897215
  • Genre: Medical
  • Number of Pages: 240
  • Language: English
  • Views: 1682
  • Downloads: 1682
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Description: In this issue of Oral and Maxillofacial Surgery Clinics, guest editor Harry Dym brings his considerable expertise to the topic of Clinical Pharmacology for the Oral and Maxillofacial Surgeon. Top experts in the field cover key topics such as a review of sedation agents, acute pain management, and more. Contains 17 relevant, practice-oriented topics including Emergency Drugs for the Oral and Maxillofacial Surgeon Office; Update on Medications for Oral Sedation in the Oral and Maxillofacial Surgery Office; Pharmacologic Treatment for Tempromandibular and TMJ Disorders; and more. Provides in-depth clinical reviews on Clinical Pharmacology for the Oral and Maxillofacial Surgeon, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.


Pdf ebook: ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

Pdf download ebook ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

Summary: With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translat

  • Author : Honghui Zhou,Frank-Peter Theil
  • Publisher: John Wiley & Sons
  • ISBN: 1118898745
  • Genre: Medical
  • Number of Pages: 472
  • Language: English
  • Views: 968
  • Downloads: 968
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Description: With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain


Pdf ebook: Clinical Pharmacology & Therapeutics

Pdf download ebook Clinical Pharmacology & Therapeutics

Summary:

  • Author : Paul Turner,C. Padgham,Alan Hedges
  • Publisher: Springer
  • ISBN: 1349059528
  • Genre: Medical
  • Number of Pages: 576
  • Language: English
  • Views: 362
  • Downloads: 362
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Description:


Pdf ebook: Symposium on Clinical Pharmacology

Pdf download ebook Symposium on Clinical Pharmacology

Summary: Symposium on Clinical Pharmacology reviews advances in clinical pharmacology, with emphasis on how to materially improve the efficacy of cancer chemotherap

  • Author : William A. Creasey,Montague Lane,Alan C. Sartorelli
  • Publisher: Elsevier
  • ISBN: 1483139409
  • Genre: Health & Fitness
  • Number of Pages: 242
  • Language: English
  • Views: 1560
  • Downloads: 1560
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Description: Symposium on Clinical Pharmacology reviews advances in clinical pharmacology, with emphasis on how to materially improve the efficacy of cancer chemotherapy. Topics range from absorption, protein binding, distribution, and excretion of antineoplastic drugs to factors affecting the biotransformation and activity of antitumor drugs. The transport of tumor-inhibitory agents across cell membranes is also examined, together with factors influencing drug selectivity and the mechanisms of clinical drug resistance. This volume is comprised of 23 chapters and begins with a brief summary of the different kinds of pharmacokinetic models and how detailed kinetic investigations of a drug in animals may provide further insight into modes of its clinical use. The next chapter considers the chief factors in determining the effective concentration of a drug at a receptor site as well as the duration and intensity of drug effect, citing antineoplastic agents as examples. The role of enzymatic activation and inactivation in drug selectivity is also discussed, along with the general mechanisms of clinical resistance to cancer chemotherapy; biochemical and pharmacological principles of combination chemotherapy; and the reaction and effects of nitrosoureas. This book will be of interest to clinicians, pharmacologists, and biochemists.